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OCR: David A Heath MB ChB FRCP Reader in Medicine, University of Birmingham Queen Elizabeth Hospital Birmingham, UK Richard J Lilford MRCOG MRCP PhD Professor of Obstetrics and Gynaecology St James's University Hospital Leeds, UK Vivian H. T. James PhD, DSc, FRCPath Unit of Metabolic Medicine, Department of Chemical Pathology St. Mary's Hospital Medical School London, UK Leighton P. Mark MD Consultant Radiologist Medical College of Wisconsin Froedtert Memorial Lutheran Hospital Milwaukee, Wisconsin, USA